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Search Results for " phospholipase a2, group iia "

Targets Recommended: Phospholipase

4

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2044	Varespladib LY315920,伐瑞拉地,伐瑞拉迪	Phospholipase	Metabolism
	Varespladib (LY315920) 是选择性group IIA, secretory phospholipase A2(sPLA2)抑制剂，其IC50=9 nM。它对大鼠，兔，豚鼠和人等各种物种血清的sPLA2活性具有明显的抑制作用，IC50分别为 8.1 nM，5.0 nM，3.2 nM 和 6.2 nM。
T30831	Cgp 43182 Cgp-43182,Cgp43182
	CGP 43182 is an effective inhibitor of group IIA secretory phospholipase A2 (Group IIA sPLA2) activity in vitro, which can be used to prevent the synergistic effect of pro-inflammatory genes stimulated by cytokines mediated by NFkappaB.
T39173	Varespladib sodium LY315920 sodium,伐瑞拉迪钠；伐瑞拉地钠
	Varespladib sodium (LY315920 sodium) is a highly potent and selective inhibitor of group IIA secretory phospholipase A2 (sPLA2), with an IC50 of 9 nM. It demonstrates significant inhibitory activity against sPLA2 in serum samples from multiple species, including rat, rabbit, guinea pig, and human, with IC50 values of 8.1 nM, 5.0 nM, 3.2 nM, and 6.2 nM, respectively.
T37331	Pyrrophenone
	The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2α with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as py...

化合物

Cat.No: T2044

Synonym: LY315920,伐瑞拉地,伐瑞拉迪

Target: Phospholipase

Cat.No: T30831

Synonym: Cgp-43182,Cgp43182

Varespladib sodium

Cat.No: T39173

Synonym: LY315920 sodium,伐瑞拉迪钠；伐瑞拉地钠

Cat.No: T37331

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04912	PLA2G2A Protein, Mouse, Recombinant (His) Pla2,sPLA2,sPla2-IIA,Mom...	Mouse	P. pastoris (Yeast)
	PLA2G2A Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 15.3 kDa and the accession number is P31482.
TMPY-01705	PLA2G2A Protein, Human, Recombinant (His) PLAS1,phospholipase A2, group	Human	HEK293 Cells
	PLA2G2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.4 kDa and the accession number is A0A024RA96.

重组蛋白

PLA2G2A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04912

Species: Mouse

Expression System: P. pastoris (Yeast)

PLA2G2A Protein, Human, Recombinant (His)

Cat.No: TMPY-01705

Species: Human

Expression System: HEK293 Cells

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